HSV-1 MacIntyre Strain Purified Virus
UN 3373
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Defined by IATA in DG Regulations 3.6.2.2.2.2 as "An infectious substance which does not meet the criteria for inclusion in Category A." This is not an indication of biosafety level, but of safety as relates to shipping in a properly prepared package.
Herpes Simplex Virus-1 (human herpesvirus-1, HHV-1) is an alpha-herpesvirus. Found in 58% of 14-49 year olds in the US. Most commonly causes cold sores (herpes simplex labialis, HSL), but can also cause genital herpes.1
Virus: Herpes Simplex Virus Type 1, MacIntyre Strain
Virus Preparation: Purified virus
Cell Line for Propagation: Vero
Suspending Buffer: 10 mM Tris, 150 mM NaCl, 1 mM EDTA, pH 7.5
Final Fill Volume: Varies by lot
Virus Particle Count: Varies by lot
Protein Concentration: [varies by lot] mg/mL by Pierce BCA protein assay method using BSA standard. Alternative methods for determining protein concentration may give different values.
Sterility: Bacteria, yeast, fungi and Mycoplasma were not detected by our assay methods.
TCID50 Titer: [varies by lot] TCID50/mL. HSV-1 is titered in Vero cells over a 7-day period with endpoint determination by cytopathic effects (CPE).
- 1. "Identification of a Herpes Simplex Labialis Susceptibility Region on Human Chromosome 21." The Journal of Infectious Diseases. 2008;197(3):340-346.
